Bromine → 6-Bromo-2-(3-methoxy-phenyl)-2-propyl-cyclohexanone

HRID 2075988노트

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HRID 2075988 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:16][CH2:17][CH3:18])[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])[CH:6]=[CH:7][CH:8]=1.[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:11]1[C:10](=[O:15])[C:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)([CH2:16][CH2:17][CH3:18])[CH2:14][CH2:13][CH2:12]1

참가 물질

4

반응물 2

HCID 24408BromineHCID 670959582-(3-Methoxy-phenyl)-2-propyl-cyclohexanone

생성물 1

HCID 670961976-Bromo-2-(3-methoxy-phenyl)-2-propyl-cyclohexanone수율 94.5%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

반응 조건

온도
50 °C

실험 절차

2-(3-Methoxy-phenyl)-2-propyl-cyclohexanone (100 mg, 0.41 mmol) was dissolved in chloroform (1 mL). To this solution bromine (68.1 mg, 0.43 mmol) in chloroform (0.5 mL) was added drop wise at −11° C. The reaction was stirred at 5° C. for 1½ hours, at room temperature for 1 hour and at 50° C. for 1 hour. The solvent was removed under reduced pressure to yield the crude title compound (126 mg) which was used directly in the next step without further purification.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-e2df7ad0133d4a8c94f57f5d9198a2f4
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07923450B2

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