Bromine → 6-Bromo-2-(4-trifluoromethoxy-phenyl)-cyclohexanone

HRID 2075992노트

반응식

HRID 2075992 반응식
[F:1][C:2]([F:18])([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][C:11]2=[O:16])=[CH:6][CH:5]=1.[Br:19]Br>C(Cl)(Cl)Cl>[Br:19][CH:12]1[C:11](=[O:16])[CH:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][C:2]([F:17])([F:18])[F:1])=[CH:9][CH:8]=2)[CH2:15][CH2:14][CH2:13]1

참가 물질

4

반응물 2

HCID 24408BromineHCID 210825892-(4-Trifluoromethoxyl-phenyl)-cyclohexanone

생성물 1

HCID 670961346-Bromo-2-(4-trifluoromethoxy-phenyl)-cyclohexanone수율 91.8%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

2-(4-Trifluoromethoxyl-phenyl)-cyclohexanone (53 mg, 0.21 mmol) was dissolved in chloroform (1 mL). To this solution bromine (34.4 mg, 0.22 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (65 mg) which was used directly in the next step without further purification.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-9d1370a153124d72bfb1f0b3e567ff88
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07923450B2

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