Bromine → 6-Bromo-2-(2-chloro-phenyl)-cyclohexanone

HRID 2076000노트

반응식

HRID 2076000 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C:9]1=[O:14].[Br:15]Br>C(Cl)(Cl)Cl>[Br:15][CH:10]1[C:9](=[O:14])[CH:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[CH2:13][CH2:12][CH2:11]1

참가 물질

4

반응물 2

HCID 24408BromineHCID 43741102-(2-Chlorophenyl)cyclohexan-1-one

생성물 1

HCID 670959316-Bromo-2-(2-chloro-phenyl)-cyclohexanone수율 112.7%

시약·촉매·용매 1

HCID 6212Chloroform용매2회

실험 절차

2-(2-Chloro-phenyl)-cyclohexanone (51 mg, 0.25 mmol) was dissolved in chloroform (1 mL). To this solution bromine (42.3 mg, 0.27 mmol) in chloroform (0.5 mL) was added drop wise at room temperature. The reaction was stirred for 1½ hours at room temperature. The solvent was removed under reduced pressure to yield the crude title compound (81 mg) which was used directly in the next step without further purification.

후처리

  1. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-3692381de02345ea9f4071bb1c056bd5
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07923450B2

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