Carbamazepine → Carbamazepine p-phthalaldehyde

HRID 2076724

반응식

HRID 2076724 반응식
[CH:1]1[CH:2]=[CH:3][C:4]2[N:15]([C:16]([NH2:18])=[O:17])[C:14]3[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=3[CH:8]=[CH:7][C:5]=2[CH:6]=1.[CH:19]1[C:24]([CH:25]=[O:26])=[CH:23][CH:22]=[C:21]([CH:27]=[O:28])[CH:20]=1>CO>[CH:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:16]([NH2:18])=[O:17])[C:4]3[CH:3]=[CH:2][CH:1]=[CH:6][C:5]=3[CH:7]=[CH:8][C:9]=2[CH:10]=1.[CH:23]1[C:24]([CH:25]=[O:26])=[CH:19][CH:20]=[C:21]([CH:27]=[O:28])[CH:22]=1

참가 물질

4

반응물 2

HCID 2554CarbamazepineHCID 12173Terephthalaldehyde

생성물 1

HCID 131728782Carbamazepine p-phthalaldehyde

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

25 mg (0.1058 mmol) carbamazepine and 7 mg (0.0521 mmol) p-phthalaldehyde were dissolved in approximately 3 mL methanol. Slow evaporation of the solvent yielded colorless needles of a 1:1 carbamazepine/p-phthalaldehyde co-crystal, as shown in FIG. 50A-B.

후처리

  1. customevaporation of the solvent

출처 및 근거

ORD 기록
ord-5dfa08e8a2384fe099b1d551c8fdab9f
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07927613B2

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