4-Amino-5-pyrimidinecarboxamide → HCID 135923523, 화합물

HRID 2076818

반응식

HRID 2076818 반응식
[NH2:1][C:2]1[C:7]([C:8]([NH2:10])=[O:9])=[CH:6][N:5]=[CH:4][N:3]=1.CO[C:13](=O)[CH2:14][O:15][CH2:16][CH2:17][C:18]1[CH:19]=[C:20]([CH3:24])[CH:21]=[CH:22][CH:23]=1.[Li+].C[Si]([N-][Si](C)(C)C)(C)C>C1COCC1>[C:20]1([CH3:24])[CH:21]=[CH:22][CH:23]=[C:18]([CH2:17][CH2:16][O:15][CH2:14][C:13]2[NH:10][C:8](=[O:9])[C:7]3[C:2]([N:1]=2)=[N:3][CH:4]=[N:5][CH:6]=3)[CH:19]=1

참가 물질

5

반응물 3

HCID 8182124-Amino-5-pyrimidinecarboxamideHCID 2733832Lithium HexamethyldisilazideHCID 67099145HCID 67099145, 화합물

생성물 1

HCID 135923523HCID 135923523, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

In analogy to example 3.3, 4-amino-5-pyrimidinecarboxamide and (2-m-tolyl-ethoxy)-acetic acid methyl ester (prepared from 2-m-tolyl-ethanol [1875-89-4] in analogy to example 3.1-3.2) reacted in the presence of LiHMDS in THF to yield the title compound (after purification of the crude product with column chromatography (silica gel, EtOAc/MeOH) and crystallization from TBME) as white solid. MS: m/e=295.5 [M−H−].

출처 및 근거

ORD 기록
ord-ca34c62bdfdf40b38c1e7d6eb9faadd6
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07928106B2

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