Dimethyl Sulfoxide → HCID 11949627, 화합물

HRID 2077083노트

반응식

HRID 2077083 반응식
[Cl:1][C:2]1[N:9]=[C:8]([NH:10][C:11]2[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=2)[CH:7]=[C:6]([CH3:17])[C:3]=1[C:4]#[N:5].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][NH2:27])[CH:19]=1.C(=O)([O-])O.[Na+].CS(C)=O>O>[ClH:1].[ClH:1].[N:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][CH2:25][CH2:26][NH:27][C:2]2[N:9]=[C:8]([NH:10][C:11]3[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=3)[CH:7]=[C:6]([CH3:17])[C:3]=2[C:4]#[N:5])[CH:19]=1

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 516892Sodium BicarbonateHCID 97937933-(2-Aminoethoxy)pyridineHCID 119835452-chloro-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile

생성물 1

HCID 11949627HCID 11949627, 화합물수율 138.5%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
130 °C

실험 절차

Compound A (13 g, 53 mmol), 2-(pyridin-3-yloxy)ethylamine (11 g, 80 mmol) and sodium hydrogencarbonate (45 g) were added to DMSO (130 ml), and the mixture was stirred at 130° C. for 20 hr. After stirring, the reaction mixture was added to cold water, and insoluble substance was filtrated (20 g). This was converted to hydrochloride to give the object compound of 2-(2-(pyridin-3-yloxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile dihydrochloride (15.5 g).

후처리

  1. stirringAfter stirring
  2. filtrationwas filtrated (20 g)

출처 및 근거

ORD 기록
ord-eb8fd9396688484d9adf5635fd6883e7
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07928126B2

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