Dimethyl Sulfoxide → HCID 67098970, 화합물

HRID 2077091노트

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HRID 2077091 반응식
[Cl:1][C:2]1[N:9]=[C:8]([NH:10][C:11]2[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=2)[CH:7]=[C:6]([CH3:17])[C:3]=1[C:4]#[N:5].[Cl:18][C:19]1[CH:28]=[CH:27][CH:26]=[CH:25][C:20]=1[O:21][CH2:22][CH2:23][NH2:24].C(=O)([O-])O.[Na+].CS(C)=O>O>[ClH:1].[Cl:18][C:19]1[CH:28]=[CH:27][CH:26]=[CH:25][C:20]=1[O:21][CH2:22][CH2:23][NH:24][C:2]1[N:9]=[C:8]([NH:10][C:11]2[CH:15]=[C:14]([CH3:16])[NH:13][N:12]=2)[CH:7]=[C:6]([CH3:17])[C:3]=1[C:4]#[N:5]

참가 물질

6

반응물 4

HCID 679Dimethyl SulfoxideHCID 516892Sodium BicarbonateHCID 27357882-(2-Chlorophenoxy)EthylamineHCID 119835452-chloro-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile

생성물 1

HCID 67098970HCID 67098970, 화합물

시약·촉매·용매 1

HCID 962Water용매

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온도
100 °C

실험 절차

Compound A (200 mg, 813 μmol), 2-(2-chlorophenoxy)ethylamine (280 μl) and sodium hydrogencarbonate (683 mg) were added to DMSO (6 ml), and the mixture was stirred at 100° C. for 27 hr. After stirring, the reaction mixture was added to cold water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and concentrated, and the residue was washed by suspending in ethyl acetate. This was converted to hydrochloride to give the object compound of 2-(2-(2-chlorophenoxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile hydrochloride (18 mg).

후처리

  1. stirringAfter stirring
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with saturated brine
  4. concentrationconcentrated
  5. washthe residue was washed

출처 및 근거

ORD 기록
ord-ebbdc95c02e143f894b3d149257e4733
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07928126B2

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