Methyl iodide → 2-(4-Chloro-2-iodophenyl)propanenitrile
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[C:4]([I:11])[CH:3]=1.[CH3:12]C(C)([O-])C.[Na+].CI>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[C:9]#[N:10])=[C:4]([I:11])[CH:3]=1참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
2-(4-Chloro-2-iodophenyl)acetonitrile (1.070 g, 3.9 mmol) was dissolved in THF (50 mL) and cooled to 0° C. Sodium tert-butoxide (0.74 g, 7.7 mmol) was added, and the solution was stirred for 10 minutes (the reaction color changed from colorless to orange.) MeI (0.24 mL, 3.9 mmol) was then added dropwise as a solution in THF (10 mL). The reaction was complete in ten minutes as determined by TLC. The crude residue was purified by silica flash chromatography using 0-15% EtOAc/hexanes. MS m/e=292 (M+H)+.
후처리
- waitThe reaction was complete in ten minutes
- customThe crude residue was purified by silica flash chromatography
출처 및 근거
- ORD 기록
- ord-a3d98c3ed2db4057ab8b35b9343f6709
- 출처 데이터셋
- uspto-grants-2011_04
- 특허 번호
- US07928139B2
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