Acetic Anhydride → 2-thiocyanatoethyl acetate

HRID 2078636노트

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HRID 2078636 반응식
[S-:1][C:2]#[N:3].[C:4]([O:7][C:8](=O)[CH3:9])(=[O:6])[CH3:5]>N1C=CC=CC=1.ClCCl>[C:4]([O:7][CH2:8][CH2:9][S:1][C:2]#[N:3])(=[O:6])[CH3:5]

참가 물질

5

반응물 2

HCID 7918Acetic AnhydrideHCID 9322Thiocyanate

생성물 1

HCID 2327002-thiocyanatoethyl acetate

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 6344Dichloromethane용매2회

실험 절차

A mixture of 2-bromoethanol (7.0 g) and potassium thiocyanate (5.4 g) in methanol (40 ml) was refluxed for 7 hours. After precipitate was filtered off, the filtrate was evaporated under reduced pressure. The residue was suspended in chloroform/methanol (5/1). The precipitate was filtered off. The filtrate was evaporated under reduced pressure to give the thiocyanate (4.4 g). To a mixture of the thiocyanate in pyridine (4.8 ml)/dichloromethane (20 ml) was added acetic anhydride (5.3 ml) in dichloromethane (5 ml) at 5° C. The mixture was stirred at room temperature for 6 hours. The precipitate was filtered off. The filtrate was washed with water, dried over sodium sulfate and evaporated under reduced pressure to give 2-thiocyanatoethyl acetate (5.6 g).

후처리

  1. filtrationThe precipitate was filtered off
  2. washThe filtrate was washed with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f271f7cbb72c49e5987e2aedb10e3a54
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07928264B2

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