Acetone → 2-Methyl-2-piperidin-1-ylpropanenitrile

HRID 20788

반응식

HRID 20788 반응식
Cl.[NH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.CC(C)=O.[C-]#N.[K+].CN(C)[C:17]1([C:22]#[N:23])[CH2:21]CC[CH2:18]1>O>[CH3:18][C:17]([N:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1)([CH3:21])[C:22]#[N:23]

참가 물질

6

반응물 4

HCID 180AcetoneHCID 9032Potassium CyanideHCID 2723721Piperidine, hydrochloride (1:1)HCID 107730491-(Dimethylamino)cyclopentanecarbonitrile

생성물 1

HCID 2888822-Methyl-2-piperidin-1-ylpropanenitrile수율 77%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound (2.33 g, 77%) was prepared from piperidine hydrochloride (2.43 g, 20 mmol), acetone (1.16 g, 20 mmol) and potassium cyanide (1.30 g, 20 mmol) in water (10 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 1.46 (2H, m), 1.50 (6H, s), 1.63 (4H, m), 2.59 (4H, m).

출처 및 근거

ORD 기록
ord-512a6c3f8abe44da91d6031f77031de6
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745642B2

연결된 노트

불러오는 중…