Mannitol → Zoledronic Acid

HRID 2079459노트

반응식

HRID 2079459 반응식
[CH:1]1[N:5]=[CH:4][N:3]([CH2:6][C:7]([P:13]([OH:16])([OH:15])=[O:14])([P:9]([OH:12])([OH:11])=[O:10])[OH:8])[CH:2]=1.O.C(O)[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O>O>[CH:1]1[N:5]=[CH:4][N:3]([CH2:6][C:7]([P:9]([OH:12])([OH:11])=[O:10])([P:13]([OH:15])([OH:16])=[O:14])[OH:8])[CH:2]=1

참가 물질

4

반응물 2

HCID 6251MannitolHCID 121586Zoledronic acid monohydrate

생성물 1

HCID 68740Zoledronic Acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

533.1 mg of zoledronic acid monohydrate (equivalent to 500 mg of zoledronic acid) and 480.0 g of mannitol are added to 7520 g of water for injection and stirred until a clear solution with a total weight of 8000 g is obtained. Each 800 g of this solution (equivalent to 50 mg of zoledronic acid) are titrated with

후처리

  1. customis obtained

출처 및 근거

ORD 기록
ord-7da73b7ec033446a9fb668c961cc3b4c
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932241B2

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