Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2079495생성일: 2026년 10월 26일
Thionyl Chloride → 4-tert-Butyl-N-[4-chloro-2-(chloro-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide
https://huagongshe.com/reaction/2079495
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-tert-Butyl-N-[4-chloro-2-(hydroxy-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide | HCID 58646038 | — |
| 생성물 | 4-tert-Butyl-N-[4-chloro-2-(chloro-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide | HCID 59485502 | — |
반응 단계
4-tert-Butyl-N-[4-chloro-2-(hydroxy-pyridin-4-yl-methyl)-phenyl]-benzenesulfonamide (1.1 g, 2.5 mmol) was dissolved in SOCl2 and heated at 80° C. overnight. Excess SOCl2 was removed by rotary evaporation. The residue suspended in 50 mL DCM was washed with saturated sodium bicarbonate solution (50 mL) and dried over MgSO4. Evaporation of solvent gave white crystalline solid. MS: (M+H)=450.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07932252B2 |
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| 출처 데이터셋 | uspto-grants-2011_04 |
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| ORD ID | ord-410e1da6702d48ffac7175cd0bc4b3ba |
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| 출처 메모 | uspto-grants-2011_04 |
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