Phosphorus oxychloride → 2-Chloro-7-methoxy-4-methylquinazoline

HRID 2079660노트

반응식

HRID 2079660 반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([CH3:14])=[N:8][C:9](O)=[N:10]2)=[CH:5][CH:4]=1.O=P(Cl)(Cl)[Cl:17]>O>[Cl:17][C:9]1[N:8]=[C:7]([CH3:14])[C:6]2[C:11](=[CH:12][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[N:10]=1

참가 물질

4

반응물 2

HCID 24813Phosphorus oxychlorideHCID 178487561HCID 178487561, 화합물

생성물 1

HCID 591992672-Chloro-7-methoxy-4-methylquinazoline수율 60%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

To 7-methoxy-4-methylquinazolin-2-ol was added POCl3 and the mixture was added heated to 100° C. for 16 h when the reaction went to completion. To the reaction mixture was added ice and water and the precipitated solid was filtered and dried on the high vacuum overnight to give 2-chloro-7-methoxy-4-methylquinazoline in 60% yield. ES/MS m/z 209 (MH+).

후처리

  1. additionthe mixture was added
  2. filtrationthe precipitated solid was filtered
  3. customdried on the high vacuum overnight

출처 및 근거

ORD 기록
ord-dc301b338bb44a8c840eebb07c5a12e1
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

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