Methyl iodide → 2,5-Dichloro-8-methoxyquinazoline
반응식
[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[C:4](=[C:5]([OH:13])[CH:6]=[CH:7][C:8]=2[Cl:12])[N:3]=1.IC.[C:16](=O)([O-])[O-].[K+].[K+]>CN(C=O)C.C(OCC)(=O)C>[Cl:1][C:2]1[N:11]=[CH:10][C:9]2[C:4](=[C:5]([O:13][CH3:16])[CH:6]=[CH:7][C:8]=2[Cl:12])[N:3]=1참가 물질
6
실험 절차
To a solution of 2,5-dichloroquinazolin-8-ol (1 eq) (See example 32 for synthesis) in DMF was added iodomethane (3 eq) and potassium carbonate (3 eq). The reaction mixture was stirred at room temperature for overnight. Diluted with ethyl acetate and washed with water and brine and dried over sodium sulfate. Filtered, evaporated and dried to provide product as a yellow solid in quantitative yield. ES/MS m/z 229.0 (MH+). Proceed for next step.
후처리
- washwashed with water and brine
- dry with materialdried over sodium sulfate
- filtrationFiltered
- customevaporated
- customdried
- customto provide product as a yellow solid in quantitative yield
출처 및 근거
- ORD 기록
- ord-d8a9731cfcf247aabd6ccb73a1975476
- 출처 데이터셋
- uspto-grants-2011_04
- 특허 번호
- US07932262B2
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