2-Nitro-4-trifluoromethylanisole → 2-Methoxy-5-(trifluoromethyl)aniline

HRID 2079681

반응식

HRID 2079681 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[N+:13]([O-])=O>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:10])([F:11])[F:12])=[CH:5][C:4]=1[NH2:13]

참가 물질

4

반응물 1

HCID 967482-Nitro-4-trifluoromethylanisole

생성물 1

HCID 6006372-Methoxy-5-(trifluoromethyl)aniline수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 4-methoxy-3-nitrobenzotrifluoride and 10% of 10% Pd/C in methanol was stirred under H2 atmosphere overnight at room temperature. The reaction mixture was filtered through celite, concentrated and dried under vacuum to provide product as an off white solid in 99% yield. ES/MS m/z 192.1 (MH+).

후처리

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationconcentrated
  3. customdried under vacuum
  4. customto provide product as an off white solid in 99% yield

출처 및 근거

ORD 기록
ord-0e11a43a96194bd6b45518dc8d910a74
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932262B2

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