1,1-Dimethylethyl 6-(2-quinolinylamino)-3-azabicyclo[3.1.0]hexane-3-carboxylate → HCID 43599085, 화합물
반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[NH:11][CH:12]1[CH:17]2[CH:13]1[CH2:14][N:15](C(OC(C)(C)C)=O)[CH2:16]2>Cl.O1CCOCC1>[CH:13]12[CH:12]([NH:11][C:2]3[CH:3]=[CH:4][C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:1]=3)[CH:17]1[CH2:16][NH:15][CH2:14]2참가 물질
4
실험 절차
tert-Butyl 6-(quinolin-2-ylamino)-3-azabicyclo[3.1.0]hexane-3-carboxylate (320 mg, 0.98 mmol) was stirred in 4M HCl in dioxane (2 ml) at r.t. under N2 for 15 min. The solvent was then removed in vacuo and the residue dried under high-vacuum and used in the next step without further purification. LCMS purity 91%, m/z 226 [M+H]+.
후처리
- customThe solvent was then removed in vacuo
- customthe residue dried under high-vacuum
- customused in the next step without further purification
출처 및 근거
- ORD 기록
- ord-2dcd32c3ced94f348897428525960df5
- 출처 데이터셋
- uspto-grants-2011_04
- 특허 번호
- US07932246B2
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