Ethyl ketone → 2-(Dimethylamino)-2-ethylbutanenitrile

HRID 20800

반응식

HRID 20800 반응식
Cl.CNC.CCC(=O)CC.[C-]#N.[K+].[CH3:14][N:15]([CH3:23])[C:16]1([C:21]#[N:22])[CH2:20][CH2:19][CH2:18][CH2:17]1>O>[CH3:14][N:15]([CH3:23])[C:16]([CH2:20][CH3:19])([CH2:17][CH3:18])[C:21]#[N:22]

참가 물질

6

반응물 4

HCID 7288Ethyl ketoneHCID 9032Potassium CyanideHCID 10473Dimethylamine, hydrochlorideHCID 107730491-(Dimethylamino)cyclopentanecarbonitrile

생성물 1

HCID 438025512-(Dimethylamino)-2-ethylbutanenitrile수율 57.5%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The title compound (8.05 g, 57.5%) was prepared from dimethylamine hydrochloride (8.154 g, 0.1 mol), 3-pentanone (8.61 g, 0.1 mol) and potassium cyanide (6.51 g, 0.1 mol) in water (50 ml) in a similar manner to that described in D1. 1H NMR (CDCl3) δ: 0.96 (6H, t, J=7.6 Hz), 1.67-1.90 (4H, m), 2.33 (6H, s).

출처 및 근거

ORD 기록
ord-046db7f9d7834ae591be4a5502da87f3
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745642B2

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