Water → 3-(2-Methylpropenyl)-benzylamine

HRID 2080132노트

반응식

HRID 2080132 반응식
[CH3:1][C:2]([CH3:12])=[CH:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[C:7]#[N:8].[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>O1CCCC1>[CH3:1][C:2]([CH3:12])=[CH:3][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7][NH2:8]

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 190247923-(2-Methylpropenyl)benzonitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 231307203-(2-Methylpropenyl)-benzylamine수율 88.7%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

3-(2-Methylpropenyl)benzonitrile described in Preparation Example 136 (0.44 g, 2.8 mmol) was dissolved in tetrahydrofuran (5 mL), lithium aluminum hydride (0.16 g, 4.2 mmol) was added under stirring at room temperature, the solution was heated to 70° C., followed by stirring for 2 hours. The reaction solution was cooled on an ice bath, then, water (0.16 mL), an aqueous solution of 15% sodium hydroxide (0.16 mL) and water (0.48 mL) were sequentially added, then, the solid was filtered, and washed with tetrahydrofuran (10 mL). The filtrate and the washings were combined, and dried over anhydrous sodium sulfate. The solvent was evaporated in vacuo, and the title compound (0.40 g, 2.48 mmol, 88.7%) was obtained as a colorless oil.

후처리

  1. temperaturethe solution was heated to 70° C.
  2. stirringby stirring for 2 hours
  3. temperatureThe reaction solution was cooled on an ice bath
  4. filtrationthe solid was filtered
  5. washwashed with tetrahydrofuran (10 mL)
  6. dry with materialdried over anhydrous sodium sulfate
  7. customThe solvent was evaporated in vacuo

출처 및 근거

ORD 기록
ord-27024e06c6c74af2aa1b67fc09de6870
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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