Methanol → HCID 58387985, 화합물
반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[CH:10][C:9]([Br:15])=[CH:8]2)=[O:4].O1CCCC1.CO.O.[OH-].[Li+:25]>O>[Li+:25].[Br:15][C:9]1[CH:10]=[N:11][C:12]2[C:7]([CH:8]=1)=[CH:6][C:5]([C:3]([O-:4])=[O:2])=[CH:14][CH:13]=2참가 물질
6
실험 절차
To a mixture of 3-bromo-quinoline-6-carboxylic acid methyl ester described in Preparation Example 162 (26 mg, 0.098 mmol) and tetrahydrofuran (2 mL) were added methanol (0.2 mL), lithium hydroxide monohydrate (4.1 mg, 0.098 mmol) and water (0.2 mL), and the solution was stirred overnight at room temperature. The solvent was evaporated in vacuo, and the title compound (27 mg) was obtained.
후처리
- customThe solvent was evaporated in vacuo
출처 및 근거
- ORD 기록
- ord-69828af9848b4de789c5f318648cb106
- 출처 데이터셋
- uspto-grants-2011_04
- 특허 번호
- US07932272B2
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