5-(4-Fluorophenoxy)furan-2-carbaldehyde → C-(5-(4-Fluoro-phenoxy)-furan-2-yl)methylamine

HRID 2080148노트

반응식

HRID 2080148 반응식
[F:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][C:7]2[O:11][C:10]([CH:12]=O)=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH3:16].CO>[Ni]>[F:1][C:2]1[CH:15]=[CH:14][C:5]([O:6][C:7]2[O:11][C:10]([CH2:12][NH2:16])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 110419065-(4-Fluorophenoxy)furan-2-carbaldehydeHCID 21705897Ammonia methanol

생성물 1

HCID 23130578C-(5-(4-Fluoro-phenoxy)-furan-2-yl)methylamine수율 81%

시약·촉매·용매 1

HCID 935Nickel촉매

실험 절차

A suspension of 5-(4-fluoro-phenoxy)-furan-2-carbaldehyde described in Preparation Example 168 (4.3 g, 20.9 mmol), Raney nickel (1.5 g) and 7N ammonia-methanol solution (40 mL) was stirred at room temperature for 15 hours under hydrogen atmosphere (1 atm). The reaction solution was filtered through Celite pad to remove the catalyst, and the filtrate was concentrated. The residue was dissolved in ethyl acetate, filtered by NH silica gel lined over a glass filter, and then, this filtrate was concentrated to obtain the title compound (3.5 g, 16.9 mmol, 81%).

후처리

  1. filtrationThe reaction solution was filtered through Celite pad
  2. customto remove the catalyst
  3. concentrationthe filtrate was concentrated
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. filtrationfiltered by NH silica gel
  6. filtrationfilter
  7. concentrationthis filtrate was concentrated

출처 및 근거

ORD 기록
ord-66a6a9f67f6d401a9c54654d1ef625cb
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932272B2

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