Sodium borohydride → (+/-)[2-Methyl-1-phenyl-2-(1-pyrrolidinyl)butyl]amine

HRID 20803노트

반응식

HRID 20803 반응식
[CH3:1][C:2]([N:7]1[CH2:11][CH2:10][CH2:9][CH2:8]1)([CH2:5][CH3:6])[C:3]#[N:4].[C:12]1([Li])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[BH4-].[Na+].CC(N1CCCC1)(C)C(N)C1C=CC=CC=1>C(OCCCC)CCC.C1COCC1.CO>[CH3:1][C:2]([N:7]1[CH2:8][CH2:9][CH2:10][CH2:11]1)([CH2:5][CH3:6])[CH:3]([NH2:4])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

8

반응물 4

HCID 4311764Sodium borohydride2회HCID 25158607[2-Methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amineHCID 438028382-Methyl-2-(1-pyrrolidinyl)butanenitrileHCID 178506676HCID 178506676, 화합물

생성물 1

HCID 59347809(+/-)[2-Methyl-1-phenyl-2-(1-pyrrolidinyl)butyl]amine수율 94%

시약·촉매·용매 3

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매HCID 8909Butyl ether용매

실험 절차

The title compound (13.4 g, 94%) was prepared from 2-methyl-2-(1-pyrrolidinyl)butanenitrile D21 (9.6 g, 0.063 mol) and phenyllithium in dibutylether (63 ml of a 2M solution; 0.126 mol) in THF (200 ml), followed by reaction with sodium borohydride (3.5 g, 0.092 mol) in methanol (200 ml) in a similar manner to that described in D5, except that after addition of the sodium borohydride stirring was continued with ice cooling for 0.5 hours then at room temperature for 66 hours. Mass spectrum (Electrospray LC/MS), ES+: Found 233 (MH+). C15H24N2 requires 232. Ret. times 0.78 and 1.06 min.

후처리

  1. waitat room temperature for 66 hours
  2. customtimes 0.78 and 1.06 min.

출처 및 근거

ORD 기록
ord-e0566abf77a540a89a8c485236349865
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745642B2

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