Isobutyraldehyde → HCID 86646581, 화합물

HRID 2080553노트

반응식

HRID 2080553 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][CH2:10][CH2:11][S:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[CH:4][CH:3]=1.[CH:22](=O)[CH:23]([CH3:25])[CH3:24].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].S([O-])([O-])(=O)=O.[Mg+2]>ClCCCl>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][N:9]([CH2:10][CH2:11][S:12][CH2:13][C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)[CH2:22][CH:23]([CH3:25])[CH3:24])=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 6561IsobutyraldehydeHCID 24083Sulfuric acid magnesium salt (1:1)HCID 5049666Sodium triacetoxyborohydrideHCID 86646582HCID 86646582, 화합물

생성물 1

HCID 86646581HCID 86646581, 화합물

시약·촉매·용매 1

HCID 111,2-Dichloroethane용매

실험 절차

This compound was made in a manner analogous to that set forth in Step A of Example 3, using 2.0 grams (0.0062 mole) of [(6-chloro(3-pyridyl))methyl]{2-[(4-methoxyphenyl)methylthio]ethyl}-amine, 0.45 gram (0.0062 mole) of isobutyraldehyde, 2.0 gram (0.0093 mole) of sodium triacetoxyborohydride and 1.5 grams (0.0124 mole) of magnesium sulfate in 40 mL of 1,2-dichloroethane. The yield of the subject compound after one column chromatography purification on silica gel, eluting with a mixture of ethyl acetate and hexanes, was 2.05 grams. The NMR spectrum was consistent with the proposed structure.

후처리

  1. customThe yield of the subject compound after one column chromatography purification on silica gel
  2. washeluting with a mixture of ethyl acetate and hexanes

출처 및 근거

ORD 기록
ord-123cf99f777941cfa21c16cf510baad6
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932393B2

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