Methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate → Methyl 2-amino-5-[4-(ethylsulfonyl)phenoxy]benzoate

HRID 2080669노트

반응식

HRID 2080669 반응식
[CH2:1]([S:3]([C:6]1[CH:25]=[CH:24][C:9]([O:10][C:11]2[CH:12]=[CH:13][C:14]([N+:21]([O-])=O)=[C:15]([CH:20]=2)[C:16]([O:18][CH3:19])=[O:17])=[CH:8][CH:7]=1)(=[O:5])=[O:4])[CH3:2].[H][H]>[Ni].CO>[NH2:21][C:14]1[CH:13]=[CH:12][C:11]([O:10][C:9]2[CH:24]=[CH:25][C:6]([S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[CH:7][CH:8]=2)=[CH:20][C:15]=1[C:16]([O:18][CH3:19])=[O:17]

참가 물질

5

반응물 2

HCID 57433573Methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 57433574Methyl 2-amino-5-[4-(ethylsulfonyl)phenoxy]benzoate수율 41.4%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

0.7 g of Raney nickel was added to a methanol (150 ml) solution of 6.98 g of methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate, and stirred overnight in a hydrogen atmosphere. The catalyst was removed through filtration, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=2/1 to 1/1) to obtain 2.65 g of the entitled compound as a colorless oil.

후처리

  1. customThe catalyst was removed through filtration
  2. customthe solvent was evaporated away under reduced pressure
  3. customthe residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=2/1 to 1/1)

출처 및 근거

ORD 기록
ord-105941c73559491bac8c38c208e349f1
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932394B2

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