Hydrochloric Acid → HCID 11670688, 화합물

HRID 2080855노트

반응식

HRID 2080855 반응식
C[O:2][C:3](=[O:38])[CH2:4][N:5]([CH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][N:25]([CH2:32][C:33]2[NH:34][CH:35]=[CH:36][N:37]=2)[CH2:26][C:27]2[NH:28][CH:29]=[CH:30][N:31]=2)=[CH:20][CH:19]=1)[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13].Cl>O>[NH:28]1[CH:29]=[CH:30][N:31]=[C:27]1[CH2:26][N:25]([CH2:24][C:21]1[CH:22]=[CH:23][C:18]([CH2:17][N:5]([CH2:4][C:3]([OH:38])=[O:2])[CH2:6][CH2:7][CH2:8][CH2:9][N:10]([CH2:14][CH2:15][CH3:16])[CH2:11][CH2:12][CH3:13])=[CH:19][CH:20]=1)[CH2:32][C:33]1[NH:37][CH:36]=[CH:35][N:34]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 11533761HCID 11533761, 화합물

생성물 1

HCID 11670688HCID 11670688, 화합물수율 74%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The compound (533.4 mg) obtained in Example 68-1 was dissolved in water (0.5 ml) and added with concentrated hydrochloric acid (2.5 ml). The whole was refluxed under heating for 30 minutes. After completion of the reaction, the solvent was distilled off, thereby obtaining a hydrochloride (384.1 mg) of the subject compound as a white solid.

후처리

  1. temperatureThe whole was refluxed
  2. temperatureunder heating for 30 minutes
  3. customAfter completion of the reaction
  4. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-4da547024b0c4f808c8a0afcbe4ccb63
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932281B2

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