(3-Chloro-4-[[(4-dipropylamino-butyl)-methyl-amino]-methyl]-phenyl)-methanol → HCID 23155409, 화합물

HRID 2080867노트

반응식

HRID 2080867 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:22][OH:23])[CH:5]=[CH:6][C:7]=1[CH2:8][N:9]([CH2:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[CH3:10]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[CH2:8][N:9]([CH2:11][CH2:12][CH2:13][CH2:14][N:15]([CH2:19][CH2:20][CH3:21])[CH2:16][CH2:17][CH3:18])[CH3:10])[CH:22]=[O:23]

참가 물질

4

반응물 1

HCID 23155369(3-Chloro-4-[[(4-dipropylamino-butyl)-methyl-amino]-methyl]-phenyl)-methanol

생성물 1

HCID 23155409HCID 23155409, 화합물수율 88.7%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6212Chloroform용매

실험 절차

The compound (290.8 mg) obtained in Example 77-4 was dissolved in chloroform (6 ml). The reaction solution was added with manganese dioxide (1.4331 g) and the whole was stirred at room temperature for 22 hours. The catalyst was filtrated out through Celite. The filtrate was concentrated under reduced pressure, thereby obtaining the subject compound (256.4 mg) as a colorless oily substance.

후처리

  1. filtrationThe catalyst was filtrated out through Celite
  2. concentrationThe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-c6437f74b1f1402fa4c82388ba496e7d
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932281B2

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