Trimethyl orthoformate → N-(4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzylidene)-N',N'-dipropyl-butane-1,4-diamine

HRID 2080896노트

반응식

HRID 2080896 반응식
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][N:7]([CH2:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=O)=[CH:18][CH:17]=1)[CH2:8][C:9]1[N:10]([CH3:14])[CH:11]=[CH:12][N:13]=1.[CH2:24]([N:27]([CH2:33][CH2:34][CH3:35])[CH2:28][CH2:29][CH2:30][CH2:31][NH2:32])[CH2:25][CH3:26].C(OC)(OC)OC>CO>[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][N:7]([CH2:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[N:32][CH2:31][CH2:30][CH2:29][CH2:28][N:27]([CH2:33][CH2:34][CH3:35])[CH2:24][CH2:25][CH3:26])=[CH:18][CH:17]=1)[CH2:8][C:9]1[N:10]([CH3:14])[CH:11]=[CH:12][N:13]=1

참가 물질

5

반응물 3

HCID 9005Trimethyl orthoformateHCID 7138396N,N-dipropylbutane-1,4-diamineHCID 866149184-[[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl]-benzaldehyde

생성물 1

HCID 67103803N-(4-{[(1H-imidazol-2-ylmethyl)-(1-methyl-1H-imidazol-2-ylmethyl)-amino]-methyl}-benzylidene)-N',N'-dipropyl-butane-1,4-diamine수율 103.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

The compound (210 mg) obtained in Example 84-5 was dissolved in anhydrous methanol (6.3 ml) and added with the compound (117 mg) obtained in Example 1-2. The solution was added with trimethyl orthoformate (297 μl) and the whole was stirred at room temperature for 6.5 hours. After completion of the reaction, the solvent was distilled off, thereby obtaining the subject compound (325 mg) as a brown oily substance.

후처리

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off

출처 및 근거

ORD 기록
ord-e7731e41b0d8455ba2f8e92f61c3a335
출처 데이터셋
uspto-grants-2011_04
특허 번호
US07932281B2

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