Isoamyl Nitrite → 2-Hydroxy-4-nitrobenzene diazonium triflate

HRID 2081927노트

반응식

HRID 2081927 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[OH:11].[F:12][C:13]([F:19])([F:18])[S:14]([OH:17])(=[O:16])=[O:15].[N:20](OCCC(C)C)=O>CO>[O-:17][S:14]([C:13]([F:19])([F:18])[F:12])(=[O:16])=[O:15].[OH:11][C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[N+:1]#[N:20]

참가 물질

5

반응물 3

HCID 8053Isoamyl NitriteHCID 62406Trifluoromethanesulfonic acidHCID 49847212-Amino-5-Nitrophenol

생성물 1

HCID 867449522-Hydroxy-4-nitrobenzene diazonium triflate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To an ice cooled solution containing 5 parts of 2-amino-5-nitrophenol and 9.6 parts of trifluoromethane sulfonic acid in 150 parts of methanol was slowly added 3.9 parts of isoamyl nitrite to complete diazotization. The solution was filtered and the filtrate was poured into 700 parts of ethyl ether. The precipitate was collected, washed with ether and dried under vacuum to give 4.5 parts of product with purity >95%.

후처리

  1. filtrationThe solution was filtered
  2. additionthe filtrate was poured into 700 parts of ethyl ether
  3. customThe precipitate was collected
  4. washwashed with ether
  5. customdried under vacuum
  6. customto give 4.5 parts of product with purity >95%

출처 및 근거

ORD 기록
ord-79b644a726fa4c86914f330be39449f8
출처 데이터셋
uspto-grants-1993_02
특허 번호
US05186865

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