Diethyl Ether → 142348-17-2

HRID 2082130노트

반응식

HRID 2082130 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17]Br.C(=O)([O-])[O-].[Na+].[Na+].CCOCC>C(O)(C)C>[Br-:13].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:8][CH2:9][N+:10]2([CH2:17][CH2:16][CH2:15][CH2:14]2)[CH2:11][CH2:12]1

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 80561,4-DibromobutaneHCID 10340Sodium CarbonateHCID 944591-(2-Pyridyl)piperazine

생성물 1

HCID 658423142348-17-2

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 40.8 g (0.25 mol) of 1-(2-pyridyl) piperazine (IV), 75.5 ml (134.9 g, 0.625 mol) of 1,4-dibromobutane (V) and 27.5 g (0.26 mol) of sodium carbonate was refluxed in 500 g of isopropyl alcohol for 16 hours, the hot mixture was filtered off from the salt precipitate, cooled, and the crystalline product was isolated. The additional amount of the product can be obtained by dilution of the mother liquor with a double volume of ether.

후처리

  1. filtrationthe hot mixture was filtered off from the salt precipitate
  2. temperaturecooled
  3. customthe crystalline product was isolated

출처 및 근거

ORD 기록
ord-40188b3f3f644e2abd31b062beccdd31
출처 데이터셋
uspto-grants-1993_02
특허 번호
US05187277

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