Ethynylcyclohexane → 2-(3-Cyclopentyl-1-propyn-1-yl)adenosine

HRID 2082284

반응식

I[C:2]1[N:3]=[C:4]([NH2:20])[C:5]2[N:6]=[CH:7][N:8]([C:18]=2[N:19]=1)[C@@H:9]1[O:17][C@H:14]([CH2:15][OH:16])[C@@H:12]([OH:13])[C@H:10]1[OH:11].[CH:21]1([C:27]#[CH:28])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1.C1(CC#C)CCCC1>>[CH:25]1([CH2:24][C:23]#[C:22][C:2]2[N:3]=[C:4]([NH2:20])[C:5]3[N:6]=[CH:7][N:8]([C:18]=3[N:19]=2)[C@@H:9]2[O:17][C@H:14]([CH2:15][OH:16])[C@@H:12]([OH:13])[C@H:10]2[OH:11])[CH2:26][CH2:21][CH2:27][CH2:28]1

참가 물질

반응물 3

HCID 70263Ethynylcyclohexane

HCID 1696622-Iodoadenosine

HCID 521007(Prop-2-yn-1-yl)cyclopentane

생성물 1

HCID 1323482-(3-Cyclopentyl-1-propyn-1-yl)adenosine수율 70.3%

실험 절차

The procedure of Example 1 was repeated except that 1.56 g (3.98 mmol) of 2-iodoadenosine was used as the starting compound and that the cyclohexylacetylene was replaced by 3-cyclopentylpropyne, whereby 1.05 g (2.8 mmol) of crystalline 2-(3-cyclopentyl-1-propynyl)adenosine was obtained (yield: 70.3%).

출처 및 근거

ORD 기록: ord-c4dab15d462d4976a7538035653ba803
출처 데이터셋: uspto-grants-1993_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05189027

연결된 노트

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