Iodoethane → 5-Chloro-2-ethoxybenzamide

HRID 2082716

반응식

HRID 2082716 반응식
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([NH2:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.I[CH2:13][CH3:14].C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH2:13][CH3:14])=[C:6]([CH:10]=1)[C:7]([NH2:9])=[O:8]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 3480945-Chloro-2-hydroxybenzamide

생성물 1

HCID 203602935-Chloro-2-ethoxybenzamide수율 36.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 5-chlorosalicylamide (16.0 g., 0.093 mole), iodoethane (31.8 g., 0.204 mole), and potassium carbonate (13.1 g., 0.095 mole) in ethanol (225 ml.) was heated under reflux for 20 hours. The hot mixture was filtered. The filtrate was reduced to dryness. The residue was triturated with water. The mixture was filtered and the collected solid recrystallized from acetonitrile to give 5-chloro-2-ethoxybenzamide (6.8 g., 36.6%) m.p. 136°-139°.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 20 hours
  3. filtrationThe hot mixture was filtered
  4. customThe residue was triturated with water
  5. filtrationThe mixture was filtered
  6. customthe collected solid recrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-173287c043d14c2db00a2ea48902ba0f
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04082751

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