Acetic Acid → 3-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

HRID 2082876노트

반응식

HRID 2082876 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([S:17](=[O:20])(=[O:19])[NH2:18])[C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5]O.C(O)(=O)C.[BrH:25]>C(OCC)C>[BrH:25].[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([S:17](=[O:20])(=[O:19])[NH2:18])[C:9]=1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[CH2:5][Br:25]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 536869293-Amino-2-benzyl-5-(hydroxymethyl)benzene-1-sulfonamide

생성물 1

HCID 202945373-Amino-4-benzyl-5-sulfamylbenzylbromide hydrobromide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

3-Amino-4-benzyl-5-sulfamylbenzyl alcohol (12.5 g; prepared as described in Example 4) is while stirring added in portions to acetic acid saturated with dry hydrogen bromide (60 ml), and the mixture is stirred for 24 hours. The resulting solution is diluted with diethyl ether (150 ml) and cooled to precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.

후처리

  1. stirringthe mixture is stirred for 24 hours
  2. temperaturecooled
  3. customto precipitate 3-amino-4-benzyl-5-sulfamylbenzyl bromide hydrobromide as a hygroscopic material with a melting point of 195°-198° C.

출처 및 근거

ORD 기록
ord-1d863e0d0f6b49e69c8cf574965082b2
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04082851

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