Oxalyl chloride → 2-Methoxy-4,6-bis(trifluoromethyl)benzoyl chloride

HRID 20835

반응식

HRID 20835 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([C:16]([F:19])([F:18])[F:17])[C:4]=1[C:5](O)=[O:6].C(Cl)(=O)C([Cl:23])=O>C(Cl)Cl.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[C:8]([C:16]([F:19])([F:18])[F:17])[C:4]=1[C:5]([Cl:23])=[O:6]

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 27412872-Methoxy-4,6-bis(trifluoromethyl)benzoic acid

생성물 1

HCID 179993452-Methoxy-4,6-bis(trifluoromethyl)benzoyl chloride수율 109.3%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-(methyloxy)-4,6-bis(trifluoromethyl)benzoic acid (20.2 g; 70.14 mmol) in dry DCM (400 mL), at 0° C., was added dropwise oxalyl chloride (13.4 mL; 154.31 mmol) followed by dry DMF (5 drops). The reaction was allowed to reach room temperature. After overnight stirring the solvent was evaporated in vacuo to get the title product (23.5 g) as a yellow slurry used without further purification.

후처리

  1. customto reach room temperature
  2. customwas evaporated in vacuo

출처 및 근거

ORD 기록
ord-865399f9efde4960829c7c9e0ae9bec4
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745642B2

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