Hydrochloric Acid → HCID 70166468, 화합물

HRID 2083820노트

반응식

HRID 2083820 반응식
CO.[ClH:3].[CH3:4][O:5][C:6](=[O:33])[C@H:7]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[NH:8][C:9](=[O:24])[C@H:10]([CH2:22][OH:23])[NH:11]C(OCC1C=CC=CC=1)=O.O>O1CCCC1.[Pd]>[ClH:3].[CH3:4][O:5][C:6](=[O:33])[C@H:7]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([OH:32])=[CH:28][CH:27]=1)[NH:8][C:9](=[O:24])[C@H:10]([CH2:22][OH:23])[NH2:11]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 13190522Z-Ser-Tyr-OMe

생성물 1

HCID 70166468HCID 70166468, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

Methanol (70 ml.) containing 6.67 ml. of 3N hydrogen chloride in tetrahydrofuran is added to a mixture of 8.328 g. of Nα -benzyloxycarbonyl-L-seryl-L-tyrosine methyl ester [cf. Fischer and Whetstone, J. Am. Chem. Soc., 76, 5076 (1954)] and 500 mg. of 20% palladium-on-carbon and the resulting mixture stirred under hydrogen at one inch water pressure for three hours. The mixture is filtered to remove the catalyst and the filtrate is evaporated to dryness under reduced pressure to give a residue of L-seryl-L-tyrosine methyl ester hydrochloride which is suitable for use without further purification.

후처리

  1. filtrationThe mixture is filtered
  2. customto remove the catalyst
  3. customthe filtrate is evaporated to dryness under reduced pressure

출처 및 근거

ORD 기록
ord-666658081b994ad580ca14b68fbb2b37
출처 데이터셋
uspto-grants-1978_04
특허 번호
US04086219

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