Pyrrolidine → (S)-N-[2-Amino-3-oxo-3-(1-pyrrolidinyl)propyl]-methane-sulphonamide Hydrochloride

HRID 2083946노트

반응식

C(OC([NH:11][CH2:12][C@H:13]([NH:17]C(OC(C)(C)C)=O)[C:14]([OH:16])=O)=O)C1C=CC=CC=1.[CH3:25][S:26]([Cl:29])(=[O:28])=[O:27].[NH:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1>>[ClH:29].[NH2:17][C@H:13]([C:14](=[O:16])[N:30]1[CH2:34][CH2:33][CH2:32][CH2:31]1)[CH2:12][NH:11][S:26]([CH3:25])(=[O:28])=[O:27]

참가 물질

반응물 3

HCID 31268Pyrrolidine

HCID 31297Methanesulfonyl chloride

HCID 2755950Boc-dap(Z)-OH

생성물 1

HCID 69891985(S)-N-[2-Amino-3-oxo-3-(1-pyrrolidinyl)propyl]-methane-sulphonamide Hydrochloride

실험 절차

Starting from (S)-3-[(benzyloxycarbonyl)-amino]-2-[(tert-butyloxycarbonyl)-amino]-propanoic acid, methanesulphonyl chloride and pyrrolidine, the expected product is obtained according to the procedure described in Example 3.

출처 및 근거

ORD 기록: ord-b2e9e7f90c664304922cfbd3a290303a
출처 데이터셋: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06716843B2

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