Isopropyl iodide → HCID 22732008, 화합물

HRID 2084056노트

반응식

HRID 2084056 반응식
[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].[H-].[Na+].I[CH:20]([CH3:22])[CH3:21]>C1(C)C=CC=CC=1.O.CN(C=O)C>[Br:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][N:8]2[CH:20]([CH3:22])[CH3:21])=[CH:4][CH:3]=1

참가 물질

8

반응물 4

HCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 24758Sodium hydrideHCID 6764936-Bromoindole

생성물 1

HCID 22732008HCID 22732008, 화합물수율 97.4%

시약·촉매·용매 3

HCID 962Water용매HCID 1140Toluene용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 6-bromoindole (2.0 g, 10 mmol), K2CO3 (2.76 g, 20 mmol), NaH (0.48 g, 20 mmol), DMF (1 ml) and 2-iodopropane (8.5 g, 50 mmol) in 40 ml of toluene was heated at 90˜100° C. for 2 hr. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulphate (Na2SO4), concentrated in vacuo and the residue purified by column chromatography on silica gel, eluting with hexanes, to give (2.32 g, 97%) of the title product.

후처리

  1. temperaturewas heated at 90˜100° C. for 2 hr
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic layer was dried over anhydrous sodium sulphate (Na2SO4)
  4. concentrationconcentrated in vacuo
  5. customthe residue purified by column chromatography on silica gel
  6. washeluting with hexanes

출처 및 근거

ORD 기록
ord-8ef3b2b1d8a54147a0783d9b8c5da062
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06716837B1

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