Hydrazine hydrate (1:1) → HCID 178434196, 화합물

HRID 2084290노트

반응식

HRID 2084290 반응식
[C:1]([CH:4]1[C:9](=[O:10])[CH2:8][C:7]([CH3:12])([CH3:11])[CH2:6][C:5]1=O)(=O)[CH3:2].O.[NH2:15][NH2:16]>C(O)C>[CH3:2][C:1]1[C:4]2[C:9](=[O:10])[CH2:8][C:7]([CH3:12])([CH3:11])[CH2:6][C:5]=2[NH:16][N:15]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 5194481,3-Cyclohexanedione, 2-acetyl-5,5-dimethyl-

생성물 1

HCID 178434196HCID 178434196, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 2-acetyl-5,5-dimethyl-cyclohexane-1,3-dione (2 g, 11.04 mmol), prepared as described in example 2, and hydrazine hydrate (1.66 ml, 33.13 mmol) in ethanol (25 ml) was stirred at room temperature for about 3 hours and then the solvent was evaporated. The residue was dissolved in dichloromethane, washed with water and brine, dried over sodium sulfate and evaporated. The title compound was obtained after chromatography on silica gel (dichloromethane:methanol=95:5) as a colourless solid (0.8 g, 45%): m.p. 103-104° C.

후처리

  1. customprepared
  2. customthe solvent was evaporated
  3. dissolutionThe residue was dissolved in dichloromethane
  4. washwashed with water and brine
  5. dry with materialdried over sodium sulfate
  6. customevaporated

출처 및 근거

ORD 기록
ord-7341d36ebd6943d69784ba4eecbad69a
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06716856B1

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