Bromotrimethylsilane → 1,5-Dibromo-2,3-dihydro-1H-indene
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:7](O)[CH2:6][CH2:5]2.[Br:12][Si](C)(C)C>C(Cl)(Cl)Cl>[Br:12][CH:7]1[C:8]2[C:4](=[CH:3][C:2]([Br:1])=[CH:10][CH:9]=2)[CH2:5][CH2:6]1참가 물질
4
실험 절차
The compound obtained in Step A (70.19 mmol) is brought into solution in 420 ml of CHCl3, and bromotrimethylsilane (13.90 ml, 105.28 mmol, 1.5 eq.) is added at room temperature. The reaction mixture is stirred overnight at room temperature. The solvent and excess bromotrimethylsilane are removed by evaporation under reduced pressure. The oil is taken up in 150 ml of CHCl3, washed with 2×80 ml of water and 3×100 ml of saturated NaCl and dried over Na2SO4. The organic phase is then concentrated under reduced pressure to yield the title compound in the form of a brown oil.
후처리
- customThe solvent and excess bromotrimethylsilane are removed by evaporation under reduced pressure
- washwashed with 2×80 ml of water and 3×100 ml of saturated NaCl
- dry with materialdried over Na2SO4
- concentrationThe organic phase is then concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-20974b9e15294dafbc8e34a64e6b255b
- 출처 데이터셋
- uspto-grants-2004_04
- 특허 번호
- US06716852B2
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