Hydrochloric Acid → 7-Methoxy-1-benzofuran-2-carbaldehyde
반응식
[C:1]([C:3]1[O:4][C:5]2[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[CH:8][C:6]=2[CH:7]=1)#N.CC(C[AlH]CC(C)C)C.C[OH:24].Cl>ClCCl.C1(C)C=CC=CC=1>[CH3:13][O:12][C:11]1[C:5]2[O:4][C:3]([CH:1]=[O:24])=[CH:7][C:6]=2[CH:8]=[CH:9][CH:10]=1참가 물질
7
실험 절차
2-Cyano-7-methoxybenzofuran (0.736 g) was dissolved in dichloromethane (10 ml), and a 1.02N DIBAL solution (5.4 ml) in toluene was added thereto at −4 to −30° C., followed by stirring for one hour. Methanol and dilute hydrochloric acid were added to the mixture, and the solvent was distilled off. The obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1) to give Compound IIad-a (0.371 g, 50%) as an oily substance.
후처리
- customat −4 to −30° C.
- distillationthe solvent was distilled off
- customThe obtained residue was purified by column chromatography (hexane/ethyl acetate=10/1)
- customto give Compound IIad-a (0.371 g, 50%) as an oily substance
출처 및 근거
- ORD 기록
- ord-5aa010a527b04073ac73dff28f5bb7a3
- 출처 데이터셋
- uspto-grants-2004_04
- 특허 번호
- US06716987B1
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