Sodium hydride → 5-isopropyl-N-[6-(4-(4,6-dimethoxy-2-pyrimidinyloxy)-2-butynyloxy)-5-(o-methoxyphenoxy)-4-pyrimidinyl]-2-pyridine sulfonamide

반응식

[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10]([NH:13][C:14]2[C:19]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH3:28])=[C:18]([O:29][CH2:30][C:31]#[C:32][CH2:33][OH:34])[N:17]=[CH:16][N:15]=2)(=[O:12])=[O:11])=[N:8][CH:9]=1)([CH3:3])[CH3:2].[H-].[Na+].[CH3:37][O:38][C:39]1[CH:44]=[C:43]([O:45][CH3:46])[N:42]=[C:41](S(C)(=O)=O)[N:40]=1>C1COCC1>[NH3:8].[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([S:10]([NH:13][C:14]2[C:19]([O:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[O:27][CH3:28])=[C:18]([O:29][CH2:30][C:31]#[C:32][CH2:33][O:34][C:41]3[N:42]=[C:43]([O:45][CH3:46])[CH:44]=[C:39]([O:38][CH3:37])[N:40]=3)[N:17]=[CH:16][N:15]=2)(=[O:12])=[O:11])=[N:8][CH:9]=1)([CH3:3])[CH3:2]