2-Benzofurancarbonitrile, 4-methoxy- → 1-(Hydroxyimino)-1-(4-methoxybenzo(b)furan-2-yl)methylamine
반응식
[CH3:1][O:2][C:3]1[C:11]2[CH:10]=[C:9]([C:12]#[N:13])[O:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.Cl.[NH2:15][OH:16].C(=O)([O-])O.[Na+]>C(O)C>[OH:16][N:15]=[C:12]([NH2:13])[C:9]1[O:8][C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:11]=2[CH:10]=1참가 물질
5
실험 절차
To a solution (40 ml) of 4-methoxybenzo(b)furan-2-carbonitrile (2.8 g) in ethanol were added hydroxylamine hydrochloride (1.2 g) and sodium hydrogencarbonate (3.0 g). The mixture was refluxed under heating for 1.5 hr. The inorganic material was filtered off and the reaction mixture was concentrated under reduced pressure to give the title compound (3.4 g) as brown crystals.
후처리
- temperatureThe mixture was refluxed
- temperatureunder heating for 1.5 hr
- filtrationThe inorganic material was filtered off
- concentrationthe reaction mixture was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-807bf9a2f3484feeb6dbf114ceb47bfe
- 출처 데이터셋
- uspto-grants-2004_04
- 특허 번호
- US06720320B2
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