7-Methoxybenzofuran-2-carbonitrile → 1-(Hydroxyimino)-1-(7-methoxybenzo(b)furan-2-yl)methylamine

반응식

[CH3:1][O:2][C:3]1[C:8]2[O:9][C:10]([C:12]#[N:13])=[CH:11][C:7]=2[CH:6]=[CH:5][CH:4]=1.Cl.[NH2:15][OH:16].C(=O)([O-])O.[Na+]>>[OH:16][N:15]=[C:12]([NH2:13])[C:10]1[O:9][C:8]2[C:3]([O:2][CH3:1])=[CH:4][CH:5]=[CH:6][C:7]=2[CH:11]=1

참가 물질

반응물 3

HCID 2985567-Methoxybenzofuran-2-carbonitrile

HCID 443297Hydroxyamine hydrochloride

HCID 516892Sodium Bicarbonate

생성물 1

HCID 30694701-(Hydroxyimino)-1-(7-methoxybenzo(b)furan-2-yl)methylamine수율 92.4%

실험 절차

By the reactions in the same manner as in Starting Material Synthesis Example 28 using 7-methoxybenzo(b)furan-2-carbonitrile (3.0 g), hydroxylamine hydrochloride (1.4 g) and sodium hydrogencarbonate (2.1 g), the title compound (3.3 g) was obtained as brown crystals.

출처 및 근거

ORD 기록: ord-7921f5c995394533b9ba8a1a8fdf7c97
출처 데이터셋: uspto-grants-2004_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06720320B2

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