Lithium hydroxide, monohydrate → 4-(6-Chloropyridin-3-yl)benzoic acid
반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.O[Li].O>C1COCC1.O>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1참가 물질
5
실험 절차
A solution of Example 252F (1.56 g, 6.4 mmol) in THF (30 mL) at room temperature treated with a solution of LiOH.H2O (0.537 g, 12.8 mmol) in water (5 mL), heated to reflux for 4 hours, cooled to room temperature and concentrated. The mixture was neutralized with 1N HCl and extracted ethyl acetate (3×50 mL). The combined extracts were washed with brine, dried (Na2SO4), filtered, and concentrated to provide the desired product. MS (APCI) m/e 234 (M+H)+.
후처리
- temperatureheated
- temperatureto reflux for 4 hours
- concentrationconcentrated
- extractionextracted ethyl acetate (3×50 mL)
- washThe combined extracts were washed with brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-5c4d7ceba39d47199d0143f5de0df654
- 출처 데이터셋
- uspto-grants-2004_04
- 특허 번호
- US06720338B2
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