Hydrochloric Acid → 4-(6-Chloronaphthalene-2-sulfonyl)-1-[methyl(4-piperidinyl)amino]-2-piperazinone hydrochloride

HRID 2086243노트

반응식

HRID 2086243 반응식
C(OC(N1CCCCC1[CH2:14][NH:15][N:16]1[CH2:21][CH2:20][N:19]([S:22]([C:25]2[CH:34]=[CH:33][C:32]3[C:27](=[CH:28][CH:29]=[C:30]([Cl:35])[CH:31]=3)[CH:26]=2)(=[O:24])=[O:23])[CH2:18][C:17]1=[O:36])=O)(C)(C)C.Cl.C(O[CH2:42][CH3:43])(=O)C>CO>[ClH:35].[Cl:35][C:30]1[CH:31]=[C:32]2[C:27](=[CH:28][CH:29]=1)[CH:26]=[C:25]([S:22]([N:19]1[CH2:20][CH2:21][N:16]([N:15]([CH3:14])[CH:43]3[CH2:42][CH2:21][NH:16][CH2:17][CH2:18]3)[C:17](=[O:36])[CH2:18]1)(=[O:24])=[O:23])[CH:34]=[CH:33]2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 8857Ethyl Acetate2회HCID 695455571-{[1-(Tert-butoxycarbonyl)piperidinyl]methylamino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone

생성물 1

HCID 227272334-(6-Chloronaphthalene-2-sulfonyl)-1-[methyl(4-piperidinyl)amino]-2-piperazinone hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of 1-{[1-(tert-butoxycarbonyl)piperidinyl]methylamino}-4-(6-chloronaphthalene-2-sulfonyl)-2-piperazinone (10.42 g) in methanol (40 ml) was combined with a 4N solution of hydrochloric acid in ethyl acetate (20 ml) and stirred at room temperature for 5 hours. The reaction mixture was combined with ethyl acetate (50 ml) and the crystals precipitated were collected by filtration, dried to obtain the title compound (9.21 g) as colorless crystals.

후처리

  1. customthe crystals precipitated
  2. filtrationwere collected by filtration
  3. customdried

출처 및 근거

ORD 기록
ord-0884c1b9927e412dbdeffe76aca42517
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06723722B1

반응 노트

불러오는 중…