Thionyl Chloride → 4-Chloro-2-(chloromethyl)pyridine--hydrogen chloride (1/1)

HRID 2086256노트

반응식

HRID 2086256 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8]O)[CH:3]=1.S(Cl)([Cl:12])=O>CN(C=O)C.C(Cl)(Cl)Cl>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][Cl:12])[CH:3]=1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 2763167(4-Chloropyridin-2-yl)methanol

생성물 1

HCID 227272744-Chloro-2-(chloromethyl)pyridine--hydrogen chloride (1/1)

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6212Chloroform용매

실험 절차

A solution of 4-chloro-2-hydroxymethylpyridine (430 mg), thionyl chloride (0.43 ml) and DMF (1 drop) in chloroform (20 ml) was heated under reflux for 2 hours. The reaction mixture was concentrated to obtain the title compound (0.44 g) as a tan powder.

후처리

  1. temperatureunder reflux for 2 hours
  2. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-3531d839c3e14f35a2bd80a678c857fc
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06723722B1

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