Sodium borohydride → (4-Chloro-6-methylpyridin-2-yl)methanol

HRID 2086261노트

반응식

HRID 2086261 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9](OCC)=[O:10])[CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([CH2:9][OH:10])[CH:3]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 22727099Ethyl 4-chloro-6-methylpyridine-2-carboxylate

생성물 1

HCID 22727138(4-Chloro-6-methylpyridin-2-yl)methanol수율 95%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of ethyl 4-chloro-6-methylpyridine-2-carboxylate (0.80 g) in methanol (30 ml) was treated at room temperature portionwise with sodium borohydride (1.51 g) and the reaction mixture was heated under reflux for 2 hours. The reaction mixture was concentrated and the resultant residue was combined with water and ethyl acetate, and the organic phase was isolated, dried and concentrated to obtain the title compound (0.60 g) as a tan powder.

후처리

  1. temperaturethe reaction mixture was heated
  2. temperatureunder reflux for 2 hours
  3. concentrationThe reaction mixture was concentrated
  4. customthe organic phase was isolated
  5. customdried
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-9fbab4c950f7460da320124c38b87706
출처 데이터셋
uspto-grants-2004_04
특허 번호
US06723722B1

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