4-Bromophenacyl bromide → N-[4-(4-Bromo-phenyl)-1H-imidazol-2-yl]-acetamide

HRID 20885

반응식

HRID 20885 반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][CH:6]=1)=O.[C:12]([NH:15][C:16]([NH2:18])=[NH:17])(=[O:14])[CH3:13]>CN(C=O)C>[Br:11][C:8]1[CH:9]=[CH:10][C:5]([C:3]2[NH:18][C:16]([NH:15][C:12](=[O:14])[CH3:13])=[N:17][CH:2]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 74544-Bromophenacyl bromideHCID 178475102HCID 178475102, 화합물

생성물 1

HCID 10468856N-[4-(4-Bromo-phenyl)-1H-imidazol-2-yl]-acetamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2-bromo-1-(4-bromophenyl)ethanone (2.00 g, 7.20 mmol) and acetylguanidine (2.18 g, 21.6 mmol) in DMF (40 mL) was stirred at rt for 48 h. The solution was concentrated to dryness in vacuo and the resulting brown solid was of sufficient purity for use in the next step. LCMS: Anal. Calcd. for C11H10BrN3O: 279, 281; found: 280, 282 (M+H)+.

후처리

  1. concentrationThe solution was concentrated to dryness in vacuo

출처 및 근거

ORD 기록
ord-9095334553934822abb0be22ce7699c7
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745636B2

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