Hydrochloric Acid → HCID 67228737, 화합물

HRID 2088662노트

반응식

HRID 2088662 반응식
C(OC(=O)[NH:7][C:8]1[C:13]([C:14](=[O:17])[CH2:15][CH3:16])=[CH:12][CH:11]=[C:10]([NH:18][CH2:19][CH2:20][NH:21]C(OC(C)(C)C)=O)[N:9]=1)(C)(C)C.[ClH:30]>O1CCOCC1.C(OCC)C>[ClH:30].[NH2:7][C:8]1[C:13]([C:14](=[O:17])[CH2:15][CH3:16])=[CH:12][CH:11]=[C:10]([NH:18][CH2:19][CH2:20][NH2:21])[N:9]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 57911744tert-Butyl[6-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-propanoylpyridin-2-yl]carbamate

생성물 1

HCID 67228737HCID 67228737, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

실험 절차

530 mg (1.30 mmol) of tert-butyl[6-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-propanoylpyridin-2-yl]carbamate (Example 24A) were dissolved in 15 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 20 h. After the reaction had gone to completion, the reaction mixture was diluted with diethyl ether (100 ml), and the precipitate was filtered off, washed with diethyl ether (100 ml) and dried. This gave 290 mg (91% of theory) of the product as a solid.

후처리

  1. filtrationthe precipitate was filtered off
  2. washwashed with diethyl ether (100 ml)
  3. customdried

출처 및 근거

ORD 기록
ord-d6a3e4019908441b8c8ff6319398847d
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436003B2

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