Hydrochloric Acid → HCID 67228770, 화합물

HRID 2088664노트

반응식

HRID 2088664 반응식
C(OC([NH:8][C:9]1[N:14]=[C:13]([NH:15][CH:16]2[CH2:21][CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17]2)[CH:12]=[CH:11][C:10]=1[C:29](=[O:32])[CH2:30][CH3:31])=O)(C)(C)C.[ClH:33]>O1CCOCC1.C(OCC)C>[ClH:33].[NH2:8][C:9]1[C:10]([C:29](=[O:32])[CH2:30][CH3:31])=[CH:11][CH:12]=[C:13]([NH:15][CH:16]2[CH2:21][CH2:20][CH2:19][NH:18][CH2:17]2)[N:14]=1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 57911742tert-Butyl 3-({6-[(tert-butoxycarbonyl)amino]-5-propanoylpyridin-2-yl}amino)piperidine-1-carboxylate

생성물 1

HCID 67228770HCID 67228770, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 312751,4-Dioxane용매

실험 절차

380 mg (0.85 mmol) of tert-butyl 3-({6-[(tert-butoxycarbonyl)amino]-5-propanoylpyridin-2-yl}amino)piperidine-1-carboxylate (Example 26A) were dissolved in 10 ml of a solution of hydrochloric acid in dioxane (4 M), and the mixture was stirred at RT for 20 h. After the reaction had gone to completion, the reaction mixture was diluted with diethyl ether (100 ml), and the recipitate was filtered off and washed with diethyl ether (100 ml) and dried. This gave 170 mg (70% of theory) of the product as a solid.

후처리

  1. filtrationthe recipitate was filtered off
  2. washwashed with diethyl ether (100 ml)
  3. customdried

출처 및 근거

ORD 기록
ord-b65d0146f27b46f28bc42372a1a9291e
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436003B2

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