Hydrochloric Acid → 7-(2,4-Dichlorophenyl)-2-(piperidin-4-yl)[1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one hydrochloride

HRID 2088677노트

반응식

HRID 2088677 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:14][C:13](=[O:15])[N:12]2[N:16]=[C:17]([CH:19]3[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]3)[N:18]=[C:11]2[CH:10]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:14][C:13](=[O:15])[N:12]2[N:16]=[C:17]([CH:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:18]=[C:11]2[CH:10]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 136104185tert-Butyl 4-[7-(2,4-dichlorophenyl)-5-oxo-5,6-dihydro [1,2,4]triazolo[1,5-c]pyrimidin-2-yl]-piperidine-1-carboxylate

생성물 1

HCID 1363378137-(2,4-Dichlorophenyl)-2-(piperidin-4-yl)[1,2,4]triazolo[1,5-c]pyrimidin-5(6H)-one hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

8.47 g (18.2 mmol) of tert-butyl 4-[7-(2,4-dichlorophenyl)-5-oxo-5,6-dihydro[1,2,4]triazolo[1,5-c]-pyrimidin-2-yl]piperidine-1-carboxylate (Example 42A) and hydrogen chloride in dioxane (4M, 90 ml) were stirred at RT for 3 h, the solvent was then concentrated to half of its original volume, diethyl ether (50 ml) was added and the reaction mixture was stirred for another 2 min. The solid was filtered off and dried. This gave 7.22 g (99% of theory) of the product.

후처리

  1. concentrationthe solvent was then concentrated to half of its original volume, diethyl ether (50 ml)
  2. additionwas added
  3. filtrationThe solid was filtered off
  4. customdried

출처 및 근거

ORD 기록
ord-3b005dccc1c04fa98db5130843813cb5
출처 데이터셋
uspto-grants-2013_05
특허 번호
US08436003B2

반응 노트

불러오는 중…