130 mg (0.19 mmol) of ethyl(4-{5-[(2-{[6-amino-5-(trifluoroacetyl)pyridin-2-yl]amino}ethyl)-amino]-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]pyrimidin-2-yl}piperidin-1-yl)acetate (Example 56A) were dissolved in 1,2-dimethoxyethane (7.5 ml), water (5 ml) and 31 mg (0.76 mmol) of sodium hydroxide were added and the reaction mixture was stirred at RT for 16 h. The mixture was then concentrated by lyophilization. This gave, after purification of the residue by preparative HPLC (Method 11), 60 mg (48% of theory) of the product as a solid.
